华中科大：发现岩藻多糖抑制肿瘤细胞转移和生长的新靶点
原标题：PDZ结合激酶/T-LAK细胞来源蛋白激酶是墨角藻中岩藻多糖抑制肿瘤细胞转移和结肠癌生长的靶点
①墨角藻中的岩藻多糖具有很高的抗肿瘤活性；
②岩藻多糖能够有效地阻止EGF引起的癌细胞转移；
③体外实验表明，岩藻多糖通过抑制丝裂原活化从而抑制结肠癌细胞生长；
④岩藻多糖直接作用于TOPK激酶，抑制TOPK的活性，从而阻止结肠癌细胞的转移和增殖。
延伸阅读
Oncotarget, 2016, 7 (14):18763-18773.
PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth
Abstract:
The fucoidan with high anticancer activity was isolated from brown alga Fucus evanescens. The compound effectively prevented EGF-induced neoplastic cell transformation through inhibition of TOPK/ERK1/2/MSK 1 signaling axis. In vitro studies showed that the fucoidan attenuated mitogen-activated protein kinases downstream signaling in a colon cancer cells with different expression level of TOPK, resulting in growth inhibition. The fucoidan exerts its effects by directly interacting with TOPK kinase in vitro and ex vivo and inhibits its kinase activity. In xenograft animal model, oral administration of the fucoidan suppressed HCT 116 colon tumor growth. The phosphorylation of TOPK downstream signaling molecules in tumor tissues was also inhibited by the fucoidan. Taken together, our fndings support the cancer preventive effcacy of the fucoidan through its targeting of TOPK for the prevention of neoplastic cell transformation and progression of colon carcinomas in vitro and ex vivo.
First Authors:
Olesia S. Vishchuk, Huimin Sun
Correspondence:
Wei Yan, Qiuhong Duan, Feng Zhu
All Authors:
Olesia S. Vishchuk, Huimin Sun, Zhe Wang, Svetlana P. Ermakova, JuanJuan Xiao, Tao Lu, PeiPei Xue, Tatyana N. Zvyagintseva, Hua Xiong, Chen Shao, Wei Yan, Qiuhong Duan, Feng Zhu
2016-02-25 Article
