《Chemico-Biological Interactions》岩藻多糖可改善胃溃疡
2020-06-19
原标题：岩藻多糖对阿司匹林诱导的大鼠胃溃疡的影响（韩国）
①阿司匹林，又称乙酰水杨酸，是一种水杨酸类药物，常用作止痛药以减轻轻微的疼痛，如退热药，退烧药和消炎药。阿司匹林还具有抗血小板或抗凝血作用，并且长期低剂量使用，以预防心脏病发作、中风、高风险人群的血凝块形成凝块等。
②尽管阿司匹林对心血管有好处，但在一些临床和临床前研究中发现了潜在的胃肠道损伤性能。阿司匹林的主要不良副作用是胃肠道溃疡、胃出血和耳鸣，尤其是在较高的剂量下。
③岩藻多糖通过抑制谷草转氨酶（AST）、谷丙转氨酶（ALT）、细胞因子（IL-10）和胃糖原的急性变化来预防溃疡。这些研究结果表明，岩藻多糖的抗溃疡特性可能有助于保护因细胞因子介导的胃粘膜氧化损伤引起的炎症。
延伸阅读
Effect of fucoidan on aspirin-induced stomach ulceration in rats
In this study, the effects of fucoidan on aspirin-induced ulcers in rats were evaluated: both biochemical and immunological parameters were taken into consideration. The status of stomach tissue glycogen storage and histological changes were also examined. Examination of basic biochemical parameters showed significant (p < 0.01) alterations in aspartate (AST) and alanine (ALT) transaminases in ulcerinduced rats. Also, moderate alterations (p < 0.05) were observed in the levels of cholesterol and blood urea nitrogen (BUN). Histopathological examination showed neutrophil infiltration and inflammation in oxyntic cells with altered glycogen storage. Analysis of serum cytokines of aspirin-induced rats showed a moderate decrease in interleukin-10 (IL-10) with considerable increase of interleukin-6 (IL-6) and interferon- (INF-) when compared with control. Administration of fucoidan showed considerable (p < 0.05) protection against ulceration by inhibiting the acute alterations of AST, ALT, cytokines and stomach glycogen. However, aggravated serum INF- was observed in the fucoidan-pretreated group. These findings suggest that the anti-ulcer property of fucoidan might contribute in protecting the inflammatory cytokine-mediated oxidative damage to gastric mucosa.
All authors:
Jong-il Choi, Hanumatha Rao Balaji Raghavendran, Nak-Yun Sung, Jae-Hun Kim, Byeong Soo Chun, Dong Hyun Ahn, Hong-Seok Choi, Keon-Wook Kang, Ju-Woon Lee.
